A multigene epilepsy panel was sent as part of her diagnostic work-up (Supplemental Table) reported two variants of uncertain significance in IER3IP1 (NM_016097.4). The first, c.239T > G (p.Leu80*), is novel and predicted to result in loss of function through protein truncation or haploinsufficiency due to nonsense-mediated decay. This evidence concerns the gene IER3IP1 and epilepsy.