In accordance with this, combined inhibition of OGT and BRD4 led to drastically reduced cell proliferation, migration, and invasion of glioblastoma cells than inhibition of BRD4 or OGT alone indicating that OGT and BRD4 act synergistically in the regulation of genes with significant roles in glioblastoma carcinogenesis and could be applied therapeutically. Here, OGT is linked to glioblastoma.