After data analysis in this experiment, we learned that the expression of MEKK3 showed an upregulated trend in PD cells and animal models, that MDMA treatment further upregulated MEKK3 expression and that overexpression of MEKK3 partially restored the effects of knockdown of MALAT1 on MDMA-induced proliferation inhibition, inflammation and NO release in PD cell models. This evidence concerns the gene MAP3K3 and Parkinson disease.