Consulting The Cancer Genome Atlas (TCGA, https://www.cancer.gov/tcga) and the International Cancer Genome Consortium (ICGC, https://icgc.org) indicated that RIPK4 is most frequently mutated in cutaneous squamous cell carcinoma, with around 25% of the patients samples harbouring RIPK4 mutations. The gene discussed is RIPK4; the disease is cutaneous squamous cell carcinoma.