The fact that mere overexpression of Elongation of Very Long Chain Fatty Acids Protein 4 (ELOVL4), an enzyme important for the long-chain fatty acids elongation cycle which is involved in skin barrier formation and whose expression is controlled by the RIPK4-IRF6 signaling axis [138, 181], is sufficient to largely delay skin tumor formation in the Pik3caH1047R;RIPK4EKO cancer model may point to a combined effect of cell autonomous and loss of skin barrier effect in these mouse models [138]. Here, RIPK4 is linked to cancer.