To test whether the reduced mHTT level in HD mouse brain was due to mHTT degradation by lysosomal‐autophagy activation and since SM3 can bring mHTT to the lysosomes, we examined if there was any alteration of the lysosomal‐autophagy proteins, including LAMP1, P62, Beclin 1 and LC3. This evidence concerns the gene MAP1LC3A and Huntington disease.