A study in a model of experimental autoimmune encephalomyelitis in mice found that Hypericum perforatum extract in combination with gold nanoparticles decreased levels of IFN-γ, IL-17A and IL-6 and increased those of TGF-β, IL-10 and IL-4 [51]. The gene discussed is TGFB1; the disease is experimental autoimmune encephalomyelitis.