IL6 and Parkinson disease: Regarding the effect of Valeriana officinalis on TNF-α levels, valerenic acid, one of the main biologically active components of Valeriana officinalis, has been found to reduce neuroinflammation and levels of proinflammatory cytokines, including TNF-α and IL-6 in brain homogenate in a model of Parkinson’s disease [30].