NFE2L2 and acute kidney injury: Flavonoids modulate oxidative stress through the pathway of nuclear factor 2 related to erythroid 2 (Nrf2), a transcription factor that regulates the expression of several cytoprotective and antioxidant genes [49]; inhibit the production of peroxynitrite, suppressing the iNOS activity and NO production; and are essential mediators of the pathological and physiological processes of AKI [50].