NME1 and cancer: GLA leads to increased levels of polyomavirus enhancer activator 3 protein (Pea3), a transcriptional repressor of human epidermal growth factor receptor 2 (HER-2/neu) in cells, and reduces HE-2/neu promoter activity, thereby reducing the likelihood of breast cancer; it also inhibits the expression of the nm-23 metastasis suppressor gene in cancer cells, thereby inhibiting angiogenesis and cancer cell migration, and achieving the effect of inhibiting the occurrence of metastasis.