GLA leads to increased levels of polyomavirus enhancer activator 3 protein (Pea3), a transcriptional repressor of human epidermal growth factor receptor 2 (HER-2/neu) in cells, and reduces HE-2/neu promoter activity, thereby reducing the likelihood of breast cancer; it also inhibits the expression of the nm-23 metastasis suppressor gene in cancer cells, thereby inhibiting angiogenesis and cancer cell migration, and achieving the effect of inhibiting the occurrence of metastasis. This evidence concerns the gene ERBB2 and breast cancer.