Two major enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), hydrolyze ACh and, up to now, pharmacological approaches for the treatment of AD mainly aim to restore acetylcholine (ACh) level in the brain through the administration of specific inhibitors (AChEI and BuChI) [7,8,9,10,11,12]. The gene discussed is BCHE; the disease is Alzheimer disease.