The expression of cyclin D1 should not be detected in normal gastric mucosa, and there are significant trends (p < 0.01) for increased expression of cyclin D1 in non-neoplastic mucosa, including in conditions such as gastric atrophy, dysplasia, intestinal metaplasia, and gastritis to gastric cancer [26]. The gene discussed is CCND1; the disease is chronic atrophic gastritis.