Natural products have been reported to have a variety of effects on the integrity of the gastrointestinal tract (GI) in patients with IBD, including effects on the alteration of signaling pathways, on the expression of several tight junction proteins (claudins, occludins, and zonula occludens proteins), on the expression of different cytokines, chemokines, complement components, and their transcription factors, on the abundance of goblet cell and the expression of mucin gene expression, and on the regulation of the cellular immune system. Here, OCLN is linked to inflammatory bowel disease.