Insulin resistance in the brain is a specific form of T2DM; however, Nigella sativa oil has a possible benefit as a disease-modifying agent for insulin resistance in the brain by suppressing oxidative stress and enhancing the brain insulin signaling pathway; multiple miRNAs are involved in this process, especially miR-34a and miR-26b [81]. The gene discussed is INS; the disease is type 2 diabetes mellitus.