In that study, positive correlations were also reported between leptin and resistin concentrations with TNF-alpha and interleukin 1β (IL-1β), with the highest levels of TNF-alpha, IL-1β, CRP, resistin, and leptin reported in persons with progressive MS [168]; some of these are positively modulated by calcitriol. The gene discussed is LEP; the disease is myeloid sarcoma.