Moreover, an increase in the systemic adiponectin level and upregulation of MAPK, as well as the suppression of PPARg expression in adipose tissue were suggested by Hadrich et al. and Scoditti et al. to underly the anti-obesity effects of olive leaf phytochemicals [96,108]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.