EGF and Uterine leiomyoma: Endothelial injury leads to the pathologic activation of angiogenic growth factors, such as the vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), and transforming growth factor (TGF-β), which leads to hyperproliferation, angiogenesis, and extracellular matrix deposition, resulting in uterine leiomyoma [7,31].