MAPT and Alzheimer disease: Further, the same study revealed that Avn has excellent neuroprotective action through directly and indirectly scavenging ROS via Nrf2 stimulation against okadaic-acid-induced Tau hyperphosphorylation and oxidative stress in SH-SY5Y cells, which has been linked critically with the neurodegenerative tauopathies in AD and PD [84,85].