Oxidative stress in AD causes the downregulation of phosphorylated PI3K, which results in the inactivation of the PI3K/AKT pathway, leading to GSK-3β activation, which translocates Nrf2 from the nucleus into cytosol, resulting in low levels of antioxidant enzymes [47,48,49,50]. This evidence concerns the gene AKT1 and Alzheimer disease.