Oxidative stress in AD causes the downregulation of phosphorylated PI3K, which results in the inactivation of the PI3K/AKT pathway, leading to GSK-3β activation, which translocates Nrf2 from the nucleus into cytosol, resulting in low levels of antioxidant enzymes [47,48,49,50]. The gene discussed is GSK3B; the disease is Alzheimer disease.