Additionally, the T2D patients with coronary artery calcification were found to have significantly higher HIF-1α levels compared to those without, and HIF-1α correlated positively with HbA1c and other factors of inflammation (CRP, IL-6) [90], which makes HIF-1α a good candidate for a marker of inflammation and glycaemic control in DM. This evidence concerns the gene IL6 and coronary artery calcification.