Intentional weight loss (including diet/exercise/surgery), especially if greater than 10%, is able to reverse the proinflammatory state linked to obesity, e.g., reducing the levels of C-reactive protein, tumor necrosis factor-α, interleukin-6 and the leptin-to-adiponectin ratio. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.