Also, Lee’s index (p < 0.001), fasting blood glucose (FBG, p < 0.05), serum insulin (FSI, p < 0.05) levels, and the homeostasis model assessment-insulin resistance (HOMA-IR) index (p < 0.01) of DIO mice were significantly higher than those of NC mice, while the homeostasis model assessment-insulin sensitivity (HOMA-IS) index was exactly opposite (p < 0.001) (Supplementary Figure S1E–I). Here, INS is linked to Insulin resistance.