Verdu et al. revealed that specific probiotic therapy attenuates antibiotic-induced visceral hypersensitivity in mice through modulating sensory neurotransmitter content (substance P) in the colon and altering visceral perception [29], while Tang et al. stated that SCFAs (produced with the bacterial fermentation of dietary fibers in the gut) are implicated in the modulation of chronic pain through several possible mechanisms [53]. This evidence concerns the gene TAC1 and hypersensitivity.