Logistic regression analysis showed that the risk of impaired sensitivity to thyroid hormones evaluated by TFIQ, PTFQI, TSHI, and TT4RI increased by 68% (OR: 1.68; 95%CI: 1.45–1.95; and p < 0.001), 70% (OR: 1.70; 95%CI: 1.46–1.97; and p < 0.001), 66% (OR: 1.66; 95%CI: 1.43–1.92; and p < 0.001), and 50% (OR: 1.50; 95%CI: 1.30–1.74; and p < 0.001), respectively, in participants with vitamin D deficiency compared with those with sufficient vitamin D after adjusting for multiple confounders. The gene discussed is TG; the disease is vitamin D deficiency.