APP and Senile plaques: The most significant differences between 10-month-old APP/PS1 mice on a HFD compared to APP/PS1 on STD (Supplementary Figure S7) were found in the polar glycolipids-gangliosides (GM2 36:1 and GM3 36:1), which were previously found to be colocalized with senile plaques and astrocytosis [29,37].