For all the above reasons, it is our opinion that a careful rethinking and reconsideration of the main role of orexin should be carried out in the scientific literature since this would translate into a different pharmacological approach to the treatment of conditions in which orexin is deficient (narcolepsy type 1) [21] or is believed to be upregulated, such as insomnia [18]. This evidence concerns the gene HCRT and narcolepsy-cataplexy syndrome.