HCRT and insomnia measurement: For all the above reasons, it is our opinion that a careful rethinking and reconsideration of the main role of orexin should be carried out in the scientific literature since this would translate into a different pharmacological approach to the treatment of conditions in which orexin is deficient (narcolepsy type 1) [21] or is believed to be upregulated, such as insomnia [18].