Overexpression of ALDH1A3 in GBM cells resulted in a significant upregulation of PAI-1 and IL-8 mRNA and protein expression in oxGBMs and a consequential increase in the release of PAI-1 and IL-8 that in turn acted on ECs in a paracrine manner, thereby stimulating neo-angiogenesis. This evidence concerns the gene SERPINE1 and glioblastoma.