Double immunofluorescence staining demonstrated a co-localization of the immunoreactivity of ALDH1A3 (red) with PAI-1 (green) (Figure 5C,D) or with IL-8 (green) (Figure 5E,F) in vessels (arrows), the peripheral cells of glomeruloid bodies (arrowheads), and in tumor cells (asterisks). The gene discussed is ALDH1A3; the disease is neoplasm.