Few investigations have put in evidence the role of NDGR2 in the context of HNSCC, but several studies proposed it as a tumor suppressor and metabolism-related gene in various cancers [61], and similarly, SLURP1, whose anti-proliferative activity is associated with nicotinic acetylcholine receptors, upon which it acts as an antagonist [62]. The gene discussed is SLURP1; the disease is cancer.