As examples, we have FN1, whose over-expression correlates with the tumorigenesis, prognosis and radioresistance of HNSCC [69], EPHB2, that induces angiogenesis via the activation of ephrin reverse signaling [70], or CAV1, typically upregulated and related to the lipid metabolism [71]. Here, FN1 is linked to head and neck squamous cell carcinoma.