Along with the increasing knowledge about key molecular alterations in meningiomas, correlations, e.g., of NF2, TRAF7, KLF4, PIK3CA, SMO, SMARCB1, POLR2A, SUFU, and POLR2A mutations or DNA methylation patterns with characteristics on routine preoperative imaging have largely been described [15,16,17,18,20,27,28]. The gene discussed is KLF4; the disease is meningioma.