Recently, we have transduced two gastric cancer cell lines with the SORE6−GFP reporter system developed by Tang et al., which relies on the activity of the transcription factors (TFs) SOX2 and OCT4 to drive the expression of the GFP reporter, i.e., after incorporation of the reporter system into cells, those that express sufficient levels of SOX2 and/or OCT4 will activate GFP expression, while those that do not express sufficient levels of these TFs remain GFP-negative [7,11]. The gene discussed is POU5F1; the disease is gastric cancer.