Interestingly, a study by Hébrant and colleagues observed, through a microarray analysis, an increase in SPRY4 mRNA expression in 10 out of 11 tumor samples from patients with ATC, when compared with papillary thyroid carcinomas (PTCs), which are less dedifferentiated tumors [49], supporting a role for this gene in ATC. Here, SPRY4 is linked to differentiated thyroid carcinoma.