Numerous studies have shown that USP14 was highly expressed in different types of tumors, for example, in epithelial ovarian cancer, esophageal squamous cell carcinoma, colorectal cancer, lung adenocarcinoma, hepatocellular carcinoma cell and prostate cancer development, the expression level of USP14 protein is higher than that of normal tissue, and it is associated with poor prognosis in tumor patients [43,44,45,46,47,48]. The gene discussed is USP14; the disease is esophageal squamous cell carcinoma.