USP14 also plays important roles in tumor death, for example, USP14 inhibits hepatocellular carcinoma apoptosis by stabilizing the GPX4 protein [49], and the inhibition of USP14 increases the degree of gastric cancer apoptosis, with an increased expression of cleaved caspase-3 and cleaved PARP [50]. This evidence concerns the gene CASP3 and neoplasm.