Cambien and colleagues demonstrated, in both immunosuppressed and immunocompetent murine models, that CXCR3 is induced by CXCL9/10/11 and mediates colorectal tumor cell metastasis as well as tumor cell survival and progression after implantation, and that systemic CXCR3 antagonism significantly reduces metastasis to the lung [41]. This evidence concerns the gene CXCR3 and colorectal neoplasm.