Regarding genetic alterations in TNBC, the main and most common alterations of this type of breast cancer are in the genes TP53, Breast Cancer 1/2 (BRCA1/2), Phosphatase and tensin homolog (PTEN), Phosphoinositide-3-kinase catalytic subunit (PI3KCA), MYC, Epidermal growth factor receptor (EGFR), Engrailed 1 (EN1), and Forkhead box C1 (FOXC1), among others [12,13]. The gene discussed is EN1; the disease is breast cancer.