Recent studies indicate that the lncRNAs HOX transcript antisense RNA (HOTAIR), growth arrest-specific 5 (GAS5), PCa gene expression marker 1 (PCGEM1), PCa ncRNA-1 (PRNCR1), PCa antigen 3 (PCA3), and PCa gene expression marker 1 (PCGEM1) interact with AR signals for CRPC progression [173,176,177,178,179]. This evidence concerns the gene PCGEM1 and posterior cortical atrophy.