Chan et al. [50] analyzed the emergence of HPCS using PCa GEMMs that recapitulated the transition from adenocarcinoma to NEPC with prostate-specific deletion of TP53, RB1, and PTEN, and identified a lineage plasticity signature of mixed luminal–basal gene markers that were unique in highly plastic cells. The gene discussed is PTEN; the disease is adenocarcinoma.