Formaggio et al. [253] implicated the overexpression of three (SOX2, OCT4, and MYC) out of the four Yamanaka factors in the dedifferentiation process of lineage plasticity observed in PCa, while the loss of the Yamanaka factor KLF4 was associated with tumor evolution [253]. The gene discussed is KLF4; the disease is posterior cortical atrophy.