PKM and leukemia: JQ1 is able to restrain the glycolysis of leukemia cell lines by downregulating the rate-limiting enzymes of glycolysis, hexokinase 2, pyruvate kinase M2 (PKM2), and lactate dehydrogenase A. This effect is also mediated by the inhibitory effect of JQ1 on c-Myc, which enhances glycolysis.