GLS and breast carcinoma: We therefore screened a panel of drugs, including chrysin (succinate dehydrogenase), CB-839 (glutaminase), GSK2837808A (lactate dehydrogenase), lonidamine (hexokinase), JQ1 (lactate dehydrogenase), and shikonin (pyruvate kinase), in escalating doses in combination with 5 mM ribitol in MDA-MB-231 breast cancer cells (Figure 2).