Caspase-9 exhibited similar patterns to caspase-8 (Figure 2C,D), with treated co-cultured U266B1 cells increasing caspase-9 cleavage 6-fold, 29-fold, and 19-fold (normal, overweight, or obese adipocytes, respectively), compared to treated non-co-cultured MM cells, and treated co-cultured RPMI 8226 cells increasing caspase-9 cleavage 6.4-fold, 5.5-fold, and 10.2-fold in (normal, overweight, or obese, respectively), compared to treated non-co-cultured MM cells. This evidence concerns the gene CASP8 and Miyoshi myopathy.