In this study, we provide the first evidence on the antiproliferative role of miR-148a-3p, showing that the overexpression of miR-148a-3p by mimic transfection exerts antitumor effects and mediates lipid peroxidation and ferroptotic cell death via the ACSL4/TFRC/Ferritin axis by targeting SLC7A11 in CRC cells. The gene discussed is ACSL4; the disease is colorectal carcinoma.