In addition, they described that HIF-1α plays a critical role in collagen biogenesis in breast tumors by upregulating the expression of P4HA1, P4HA2, PLOD1, and PLOD2 hydroxylases as well as the lysyl oxidase family members LOX, LOXL2, and LOXL4. The gene discussed is LOXL4; the disease is breast neoplasm.