In addition, transforming growth factor (TGF)-β, an immune-suppressing cytokine in the microenvironment of breast cancer, inhibits members of the miR-200 family, which inhibit tumor invasion and metastatic dissemination by targeting the EMT inducing transcription factor ZEB-1, which is involved in the hypoxia-regulated microenvironment and bone metastasis [50,51]. The gene discussed is ZEB1; the disease is breast cancer.