The cell is equipped with a heterogeneous group of PRRs that includes but is not limited to Toll-like receptors (TLR3, TLR7, TLR8, and TLR9); the RNA sensors RIG-I (retinoic acid-inducible gene I), MDA5 (melanoma differentiation-associated protein 5), and LGP2 (RIG-I-like receptor LGP2); and the DNA sensors cGAS (cyclic GMP-AMP synthase) and AIM2 (absent in melanoma 2) [129]. The gene discussed is IFIH1; the disease is melanoma.