The PDSOs accurately reflected the mutational and copy number profiles of the original tumor tissue, with only minor changes observed in the cell models, such as in chromosome 9 from MPNST.Sarcomas commonly exhibit alterations in tumor suppressor genes like TP53 and CDKN2A, which disrupt the regulation of the cell cycle.Recurring mutations in genes such as ATM, STAG2, MSH2, MSH6, and PTEN indicate DNA repair defects that align with the genomic instability observed in sarcomas. Here, MSH6 is linked to sarcoma.