Hematoxylin and eosin (H&E) stain, both the PDSOs and matched patients’ tumor showed atypical spindle cell proliferation in LMS, LS, and DFSP patients.Both PDSOs and patients’ tumor displayed similar expression of markers, including Ki67, CD34, PARP1, VIM, and MMP9. The gene discussed is MMP9; the disease is neoplasm.