Using three-level exon array data (gene, exon, and network) and additional separate differential expression analyses, Significance Analysis of Microarrays (SAM), and Linear Models for MicroArray data (LIMMA), ATP8B1 was found to be a novel gene associated with CRC that shows changes at cytogenetic, gene and exon levels [45]. This evidence concerns the gene ATP8B1 and colorectal carcinoma.