MDM4 and central nervous system cancer: In contrast, CEP-1347 neither reduced the expression of MDM4 nor increased the expression of p53 and its target gene products in T98G, a glioblastoma cell line expressing a mutant p53; this was in line with our previous finding that CEP-1347 inhibits MDM4 expression and the p53 pathway specifically in wild-type p53 glioma cells [12].