NOTCH1 and neoplasm: However, there are clearly NOTCH-family-receptor-specific effects as well, as deletion of Notch1 or Notch2 had slightly different effects on tumour phenotype (Figure 3E,F) and tumour gene expression (Figure 4), in particular, the number of MSCC tumours, suggesting a role of NOTCH2 in the regulation of EMT; links between NOTCH and EMT have been previously suggested [25].