Circulating ECM markers, reflecting bone resorption (e.g., CTX-I (C-terminal telopeptide of type-1 collagen), and MMP-3 (matrix metalloproteinase-3)) may emerge as complementary tools to the conventional dual X-ray absorptiometry (DEXA) scans of the skeleton for detection of osteopenia in patients with MPNs. This evidence concerns the gene MMP3 and Osteopenia.