In more detail, three studies have shed light on the prognostic role of Beclin-1 in CCA [18,19,20] and two studies have assessed LC3B ± p62 only in iCCA [21,22], while no study has addressed the impact of active autophagy in all histopathological subtypes, including SD- and LD-iCCA. This evidence concerns the gene MAP1LC3B and cholangiocarcinoma.