Importantly, overexpression of miR-15b, mimicking CR’s effects on this miR, inhibits basal-like mammary cancer cell proliferation, indicating that reduced IGF1R, and possibly the reduction of other miR-15b targets such us BCL2, BCL2L2, CCND1, and CCNE1, contribute to the anticancer effects observed with CR in the C3-TAg mouse model and associated in vitro models. The gene discussed is CCND1; the disease is breast cancer.