SMURF2 and familial pancreatic carcinoma: However, in other studies, the expression of miR-15b was identified to be upregulated in pancreatic cancer cell lines and tissues, and the overexpression of miR-15b enhanced pancreatic cancer cell invasion, growth, and EMT via regulating the expression of SMURF2. Additionally, studies have shown that the expression of miR-15b promote cell growth in MDA-MB-231 [91], and it was downregulated in cells in response to 48 h of serum starvation and 1 μM doxorubicin treatment for 24 h [92].