A difference in upregulated HSPs was noted between tumors and normal tissue, with an overall increase of HSP90, GRP75, and Ubiquitin+1 seen in normal tissues compared to a decrease in tumor tissues; an increase in HSP27, HSP32, HSP40, HSP60 protein expression levels were observed in tumor tissues as compared to normal tissue and only HSP70 expression was increased in both normal and tumor tissue after HIPEC exposure [94]. Here, HMOX1 is linked to neoplasm.