On the other hand, patients with a metastatic GIST bearing a PDGFRa D842V mutation had the best survival, with a median OS not reached at the time of data cutoff, but a disease refractory to existing TKI, illustrated by TNT in the first, second and third lines of 5.4 months, 9.4 months and 5.8 months, respectively. This evidence concerns the gene PDGFRA and gastrointestinal stromal tumor.