Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K), an important kinase involved in the PI3K/AKT1/MTOR pathway, plays a crucial role in the growth and proliferation of various solid tumors, and PIK3CA is one of the most frequently mutated genes in CRC [25]. This evidence concerns the gene AKT1 and colorectal carcinoma.