The majority CRC patients follow the conventional chromosomal instability (CIN), which is started by several mutations such as APC, followed by genetic alterations in KRAS, PIK3CA and SMAD4, as well as the hyperactivation of pathways such as Wnt/TGFβ/PI3K. The gene discussed is TGFB1; the disease is cervical squamous intraepithelial neoplasia.