Many patients with CRC had conventional chromosomal instability (CIN), which is started by several mutations such as APC, followed by genetic alterations in KRAS, PIK3CA, and SMAD4, as well as the hyperactivation of pathways such as Wnt/TGFβ/PI3K. This evidence concerns the gene TGFB1 and cervical squamous intraepithelial neoplasia.