AFP and cancer: Frazier et al., in a summary of seven trials conducted by the Children’s Oncology Group and the Children’s Cancer and Leukemia Group, suggested that AFP levels above 10,000 ng/mL at diagnosis were associated with a worse prognosis, indicated by lower event-free survival (EFS) and overall survival (OS), although statistical significance was not achieved (p = 0.45) [5,60].