Recently, we reported that overexpressed tumor necrosis factor receptor 1 (TNFR1) induced lung SCC cell dedifferentiation and metastasis to the liver in KA/KA mice [10] and that TNFR2 in CD4 T cells was required for generating an immunosuppressive tumor microenvironment (iTME) for promoting lung ADC progression in KrasG12D;Ikka∆LU mice [11]. The gene discussed is CD4; the disease is neoplasm.