Of note, TNF treatment of KALLU+ cells elevated UBCH10 and downregulated E-cadherin and K5 levels, whereas, knocking down UBCH10 elevated K5 and E-cadherin levels, indicating that TNF/TNFR1 and UBCH10 lead a program that switches differentiation and dedifferentiation or EMT of SCC cells, which determines a tumor’s regression or progression. Here, UBE2C is linked to neoplasm.