To determine the mechanism by which intrinsic TNFR1 modulates tumor cell fates, we used Scal1 and CD24 stem cell markers to isolate KALLU+ lung SCC cells with high stemness (Scal1highCD24low) features and KALLU- cells with low stemness (Scal1lowCD24high) features from a previously reported parental KALLU lung SCC cell line derived from KA/KA lung SCCs [1,10]. This evidence concerns the gene TNFRSF1A and neoplasm.