The lung SCCs derived from KA/KA mice exhibited the classical SCC features with keratin pearls and increased K5, p63, and Ki67 positive cells, and expressed reduced p53, Rb, and LKB1 tumor suppressors but elevated EGFR activity, ERK activity, c-Myc, Trim29, Rhov, Nanog, and ROS1 levels [1]. The gene discussed is KRT5; the disease is neoplasm.