AKT1 and glioblastoma: Mouse GL261 GBM cells showed a similar elevation in AKT1 phosphorylation to 216.1% and 190.9% for co-cultivation with 3.0 × 104/mL THP-1 cells or conditioned media, and these values were also decreased to 136.9% and 146.1% by ACT-209905, respectively (Figure 6c,d).